Toxicology Studies

Orally (gavage, capsule, fortified diet, drinking water), Parenteral (intravenous bolus and infusion, intramuscular, subcutaneous), ocular, intranasal, inhalation etc.

  • Maximum Tolerated Dose (MTD) toxicology studies in Mice/Rats/Rabbits
  • Maximum Tolerated Dose (MTD) toxicology studies in non-rodents (Beagle dog/Minipigs/NHP*)
  • Dose range finding (7 to 14 day) toxicology studies in Mice/Rats
  • Dose range finding (7 to 14 day) toxicology studies in non-rodents (Beagle dog/Minipigs/NHP*)
  • 28-day repeat dose toxicity studies with toxicokinetics in Mice/Rats/Rabbits
  • 28-day repeat dose toxicity studies with toxicokinetics in non-rodents (Beagle dog/Minipigs/NHP*)
  • 28-day neurotoxicity study in rodents
  • 90-day repeat dose toxicity studies with toxicokinetics in Mice/Rats/Rabbits
  • 90-day repeat dose toxicity studies with toxicokinetics in non-rodents (Beagle dog/Minipigs/NHP*)
  • 90-day neurotoxicity study in rodents
  • 6/12 month repeat dose toxicity study with toxicokinetics in Mice/Rats
  • 9/12 month repeat dose toxicity study with toxicokinetics in non-rodents (Beagle dog/Minipigs/NHP*)
  • 24 -Month carcinogenicity study in rats
  • MTD/DRF study using non-transgenic (wild type)
  • 6 -Month carcinogenicity study using Transgenic Mice with toxicokinetics

*: In-life studies will be performed in partner lab and all rest of evaluations done at Adgyl.