Our in vitro toxicity testing services provide reliable, human-relevant safety assessment using validated alternative methods. These assays are designed to support regulatory requirements while promoting ethical testing practices and reducing reliance on animal studies.
We offer scientifically robust in vitro approaches to assess skin and eye irritation assays, endocrine disruption assays, and phototoxicity and dermal absorption assays using internationally accepted OECD-aligned models. In addition to OECD test methods, we also provide in silico analysis to support safety assessment. These approaches enable accurate evaluation of local toxicity endpoints using reconstructed human tissue systems that closely reflect human biological responses.
Together, these in vitro assays support integrated testing strategies for food additives, agrochemicals, medical devices, industrial chemicals, and pharmaceuticals helping clients generate regulatory-ready safety data efficiently while aligning with global expectations for alternative testing and the 3R principles.
In vitro skin corrosion: Reconstructed Human Epidermis (RhE) test method
In vitro skin irritation: RhE test methods
In vitro skin sensitisation assay- Direct Peptide Reactivity Assay (DPRA)
In vitro skin sensitisation assay-KeratinoSens assay
In vitro skin sensitisation assay- Human Cell Line Activation Test (hCLAT)
In vitro eye irritation assay: Reconstructed Human Cornea-like Epithelium (RhCE) test
RhCE test method for eye hazard identification
Bovine corneal opacity and permeability test method
Estrogen Receptor Transactivation Assays (ERTA)
H295R Steroidogenesis assay
Androgen Receptor Transactivation Assays (ARTA)
Human Recombinant Estrogen Receptor (hrER) - ER binding affinity (under validation)
Aromatase assay (under validation)
In vitro phototoxicity (Balb/c 3T3)
In vitro phototoxicity - RhE phototoxicity test method
In vitro dermal absorption (Franz cell) assay
Adgyl Lifesciences is committed to ensure
Scientifically rigorous, reproducible and timely study execution.
High‑quality data generation aligned with scientific & regulatory requirements
Seamless end‑to‑end support spanning study design, execution, and data interpretation.
Yes, we can recommend an integrated testing approach combining multiple assays (e.g., skin and eye irritation assays, endocrine disruption assays, and phototoxicity and dermal absorption assay) for comprehensive safety assessment.
We provide rapid in vitro screening assays across organ toxicity screening (liver, kidney,) dermatological, ocular, phototoxic, and endocrine endpoints to support early decision-making.
Yes, we can develop and optimise tailored assays/bioassays depending on your molecule, pathway, or biomarker of interest.
We provide immune profiling (cytokines, TILs), checkpoint assays (PD-1/PD-L1), and functional immune assays to support immunology and oncology programs.
NAMs such as organ-on-chip, spheroids, organoids, and genomics platforms offer more predictive, human-relevant data while reducing reliance on animal testing.