Orally (gavage, capsule, fortified diet, drinking water), Parenteral (intravenous bolus and infusion, intramuscular, subcutaneous), ocular, intranasal, inhalation etc.
- Maximum Tolerated Dose (MTD) toxicology studies in Mice/Rats/Rabbits
- Maximum Tolerated Dose (MTD) toxicology studies in non-rodents (Beagle dog/Minipigs/NHP*)
- Dose range finding (7 to 14 day) toxicology studies in Mice/Rats
- Dose range finding (7 to 14 day) toxicology studies in non-rodents (Beagle dog/Minipigs/NHP*)
- 28-day repeat dose toxicity studies with toxicokinetics in Mice/Rats/Rabbits
- 28-day repeat dose toxicity studies with toxicokinetics in non-rodents (Beagle dog/Minipigs/NHP*)
- 28-day neurotoxicity study in rodents
- 90-day repeat dose toxicity studies with toxicokinetics in Mice/Rats/Rabbits
- 90-day repeat dose toxicity studies with toxicokinetics in non-rodents (Beagle dog/Minipigs/NHP*)
- 90-day neurotoxicity study in rodents
- 6/12 month repeat dose toxicity study with toxicokinetics in Mice/Rats
- 9/12 month repeat dose toxicity study with toxicokinetics in non-rodents (Beagle dog/Minipigs/NHP*)
- 24 -Month carcinogenicity study in rats
- MTD/DRF study using non-transgenic (wild type)
- 6 -Month carcinogenicity study using Transgenic Mice with toxicokinetics
*: In-life studies will be performed in partner lab and all rest of evaluations done at Adgyl.
