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Drug Discovery Services
Case Studies
Candidate Nomination in Record Time
CHALLENGES:
Fast follow on: competitors in phase I/II
Therapeutic indication: Identify new indication(s) other than competitors and/or differentiation over current indication in clinic
Identify novel hit for analoging in absence of HTS screen
Deliver CCN in two years
EUROFINS ADVINUS APPROACH:
Novel and diverse six chemotypes designed to carry out parallel SAR to identify HITS in first three months
Identified four HITS and prioritized two series to provide two LEADS within 6 months
Developed novel
in-vivo
PD Assay
Nominated Optimized Lead for Candidate Selection within 10 months,
Progress was halted due to phototoxicity and human hepatocyte instability
Second lead series showed CYP TDI liability
SAR knowledge from earlier two series helped to design a new chemotype (Third) to overcome above hurdles in time
Identified new indication by exploring efficacy in various disease models and data mining with clients help
Identified clinical candidate with excellent efficacy and good therapeutic window and potential back-up compound is being profiled
ACHIEVEMENTS:
Filed three chemical composition of matter patents
This programs achieved clinical candidate nomination milestone from collaborator
CURRENT STATUS:
Nominated clinical candidate is being profiled for new indication and
IND enabling studies
ongoing.